Calcium Carbonate with Vitamin D3 Suspension
This combination is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medicationssuch as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.
Calcium is required by the human body. Normal neuron, cell, muscle, and bone function is dependent on it. If the blood contains insufficient calcium, the body will pull calcium from the bones, weakening them. Vitamin D enhances the body’s absorption of calcium and phosphorus. It is critical to get adequate vitamin D, calcium, and phosphorus to build and maintain strong bones.
Description
Uses for Calcium Carbonate with Vitamin D3 Suspension
This combo drug is intended to prevent or treat low blood calcium levels in patients who do not consume enough calcium. It can be used to treat disorders caused by low calcium levels, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased parathyroid gland function (hypoparathyroidism), and a specific muscle ailment (latent tetany). It may also be used to ensure that certain patients obtain enough calcium (including women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium is essential to the human body. It is required for normal neuron, cell, muscle, and bone function. If there is insufficient calcium in the blood, the body will draw calcium from the bones, weakening them. Vitamin D aids in the absorption of calcium and phosphorus by the body. Getting enough vitamin D, calcium, and phosphorus is essential for creating and maintaining strong bones.
Important: The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate, or effective for you. Consult with your healthcare professional before taking any medication.
This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (including women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.
How to use Calcium 600-VIT D3
Take this medication by mouth with food. If your product contains calcium citrate, then it may be taken with or without food. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your total daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. If you have any questions, ask your doctor or pharmacist.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
If you are taking the chewable form of this medication, chew thoroughly before swallowing. If you are taking capsules, swallow each capsule whole.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.
Calcium supplements come in different forms that contain different amounts of calcium/vitamin D. Ask your doctor or pharmacist to help select the best product for you.
If you think you may have a serious medical problem, seek immediate medical attention.
Special Precautions
Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when using in patients with history of kidney stones. Renal impairment; frequent monitoring of serum calcium and phosphorus is recommended.
Other Drug Interactions
May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hours before calcium-containing preparations.
Other Interactions
Food Interaction
Foods that are rich in oxalic acid (e.g. spinach and rhubarb) and phytic acid (e.g. whole cereals) may reduce calcium absorption by formation of insoluble calcium salts, thus calcium products should not be taken within 2 hr of eating such foods.
Dosage
Oral
Supplementation of calcium and vitamin D3
Adult: As effervescent tablet containing calcium carbonate 1500 mg and vitamin D3 10 mcg: 1 tablet bid, to be dissolved in a glass of water and taken immediately. Dosing regimen may vary with brands and dosage forms.
Vitamin D3 + Calcium Carbonate and Other Contraindications
Patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia.
Storage
Oral
Store below 25°C.
Lab interference
Oral
Store below 25°C.
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Indications and Dosage
Oral
Calcium deficiency, Vitamin D deficiency Adult: Available preparations:
Ca carbonate 1,500 mg (equivalent to 600 mg elemental Ca) and vitamin D3 10 mcg (equivalent to 400 IU) conventional tab Ca carbonate 1,500 mg (equivalent to 600 mg elemental Ca) and vitamin D3 10 mcg (equivalent to 400 IU) chewable tab Ca carbonate 1,500 mg (equivalent to 600 mg elemental Ca) and vitamin D3 10 mcg (equivalent to 400 IU) effervescent tab Ca carbonate 1,250 mg (equivalent to 500 mg elemental Ca) and vitamin D3 11 mcg (equivalent to 440 IU) effervescent granules for oral solution Prophylaxis and treatment: Dosage must be individualised according to the patient’s deficit or daily maintenance requirements. As 1,500 mg/400 IU conventional and chewable tab: 1 tab bid, preferably 1 tab in the morning and 1 tab in the evening. As 1,500 mg/400 IU effervescent tab: 1 tab bid dissolved in approx 200 mL of water, preferably 1 tab in the morning and 1 tab in the evening. As 1,250 mg/440 IU effervescent granules: 1 or 2 sachets daily, dissolved in a glass of water. Dosage recommendations may vary among individual products and between countries (refer to detailed product guideline). |
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Administration
Should be taken with food.
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Contraindications
Nephrolithiasis, nephrocalcinosis, hypervitaminosis D, hypercalcaemia, hypercalciuria; diseases leading to hypercalcaemia or hypercalciuria (e.g. bone metastases or other malignant bone diseases, myeloma, primary hyperparathyroidism). Severe renal failure and impairment.
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Special Precautions
Patient with achlorhydria, hypoparathyroidism; risk factor for hypercalcaemia (e.g. sarcoidosis), history of kidney stones, high tendency to calculus formation. Immobilised patients with osteoporosis. Mild to moderate renal impairment. Elderly. Pregnancy and lactation.
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Adverse Reactions
Significant: Hypercalcaemia, Milk-alkali syndrome, constipation, bloating, flatulence.
Gastrointestinal disorders: Nausea, abdominal pain, diarrhoea. Immune system disorders: Hypersensitivity reactions. Renal and urinary disorders: Hypercalciuria. Skin and subcutaneous tissue disorders: Rarely, rash, pruritus, urticaria. |
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Monitoring Parameters
Monitor serum Ca levels and renal function (e.g. serum creatinine).
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Overdosage
Symptoms: Hypercalcaemia characterised by anorexia, thirst, vomiting, nausea, abdominal pain, muscle weakness, fatigue, mental disturbances, polyuria, polydipsia, nephrocalcinosis, bone pain, renal calculi, and cardiac arrhythmia and coma in severe cases. High amounts of Ca ingestion may cause Milk-alkali syndrome, irreversible renal damage and soft calcification. Management: Discontinue use of Ca carbonate and vitamin D3 treatment. Empty contents of the stomach in patients with impaired consciousness, rehydrate, and based on the severity may consider combined or isolated treatment with bisphosphonates, loop diuretics, corticosteroids and calcitonin. Closely monitor serum electrolytes, renal function and diuresis.
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Drug Interactions
May enhance the arrhythmogenic effects of cardiac glycosides.
Calcium carbonate: Increased risk of hypercalcaemia with thiazide diuretics. May decrease the gastrointestinal absorption of bisphosphonates, Na fluoride, quinolones, tetracyclines, levothyroxine, Fe, zinc and strontium. Ca absorption may be reduced by systemic corticosteroids. Vitamin D3: Decreased effects with phenytoin, barbiturates, rifampicin, glucocorticosteroids. May reduce gastrointestinal absorption with colestyramine or paraffin oil. |
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Food Interaction
Food may increase Ca absorption. Bran, foods high in oxalates, or whole grain cereals may decrease Ca absorption.
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Action
Description: Ca and vitamin D3 administration counteracts the rise of PTH that is caused by Ca deficiency and increased bone resorption.
Calcium carbonate is used as a supplementary source of Ca to help prevent or decrease the rate of bone loss in osteoporosis. It also acts as an antacid by neutralising gastric acidity resulting in increased gastric and duodenal pH. Vitamin D3 is a fat-soluble sterol essential for the proper regulation of Ca and phosphate homeostasis, bone metabolism and mineralisation. Synonym: vitamin D3: colecalciferol, cholecalciferol. Pharmacokinetics: Absorption: Calcium carbonate: Absorbed from the gastrointestinal tract, predominantly in the duodenum. Vitamin D3: Well-absorbed from the gastrointestinal tract (in the presence of bile). Distribution: Enters breastmilk. Calcium carbonate: Primarily in bones and teeth. Plasma protein binding: Approx 40%, to albumin. Metabolism: Calcium carbonate: Converted into Ca chloride by gastric acid. Vitamin D3: Metabolised in the liver by vitamin D 25-hydroxylase via hydroxylation into active metabolite, 25-hydroxycolecalciferol; further converted in the kidneys by vitamin D 1-hydroxylase to form the active 1,25-dihydroxycolecalciferol (calcitriol). Excretion: Via faeces and urine. |