Cjc 1295 Ipamorelin Blend Dosage For Weight Loss

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If you are looking for Cjc 1295 Ipamorelin Blend Dosage For Weight Loss , we would like to talk with you. We can help you find the best legal Cjc 1295 Ipamorelin Blend Dosage For Weight Loss .Injectable CJC-1295 It is a potent MGF (mammoth growth factor) releaser. The benefits of combining MGF and IGF-1 are three fold: 1. You get the anabolic and lipolytic activity of the two substances; 2. The level of IGF-1 activity obtained will be significantly greater than when using IGF-1 alone; 3. There is no need to redose, as in the case of administering separate injections of pure MGF and pure IGF-1.

What is CJC 1295?

CJC 1295 directly binds to the receptors for growth hormone-releasing hormone on your pituitary gland. Research has shown that in men and women between the ages of 21 and 61, CJC 1295 increased serum growth hormone levels by 200-1000%. This elevated release of growth hormone continued for approximately six days as CJC 1295 has a half-life of 6-8 days. Longer half-lives mean the body continues to respond to the injection well beyond the time of administration. CJC 1295 has been shown to be safe to increase growth hormone concentrations without the harsh side effects experienced with human growth hormone treatments.

Introduction

Formula:C152H252N44O42

Structure:Tyr-D-Ala-Asp-Ala-lle-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-lle-Leu-Ser-Arg

CJC-1295, Growth Hormone Releasing Hormone (GHRH), is a synthetic secretalogue which stimulates HGH release. In the body, large amounts of growth hormone are stored in the pituitary. GHRH affects the number of secreting cells and the amount they are able to secrete. 

CJC 1295 (with & without DAC)

Since a lot of peptide companies are producing CJC 1295 with and without DAC I thought it would be helpful to review both. CJC 1295 with DAC (aka Drug Affinity Complex) is known as a long-acting GHRH (growth hormone stimulating hormone). However, regardless. of whether CJC 1295 is the DAC version or not its primary purpose is to boost protein synthesis levels and help fuel the growth of muscle tissue in the body.

Some claim CJC 1295 with DAC has an advantage over CJC 1295 (without DAC) given it does not have a limited duration of action. However, others believe we should be concerned about unregulated and inconsistent hGH release associated with DAC’s extended release. I fall into the latter group based on my functional medicine foundation.

A study of healthy participants between the ages of 21 and 61 found that CJC 1295 with DAC prolonged elevated levels of growth hormone as well as IGF-1 with no increase in prolactin, leading to fat loss and increased muscle mass via improved protein synthesis. 

CJC 1295 DAC can be used for relatively short periods since it lengthens the duration of the body’s natural hGH secretion. However, your dose timing doesn’t impact your body’s decision when those natural GH peaks occur, which isn’t exactly advantageous. So, for example, if your blood sugar is high during one of those hGH peaks, then hGH will not convert to IGF-1, and you will lose the benefits. Another thing to be cautious of with CJC 1295 DAC is that its effects on longevity are not thoroughly understood. In a podcast with Ben Greenfield, Jean Tremblay mentioned that the university team who discovered the peptide had seen the mice who were on CJC 1296 DAC die a horrible death. There is a working theory this is due to the irregularity of hGH spikes. 

CJC 1295 without DAC, on the other hand, does not come with the same warning and is the preferred compound clinically. A reminder that it’s essential to do your research and work with a member of the International Peptide Society to make sure you are safe while working towards your health goals. 

CJC 1295 stimulates growth hormone secretion and will keep a steady increase of hGH and IGF-1, leading to fat loss and muscle growth. With no increase in prolactin and better stimulation and release of hGH, clinical results showcase fat loss, increased lean muscle mass, and better lipid profiles. Another benefit of this peptide is its ability to promote slow-wave sleep (e.g. Delta sleep), which is the sleep stage associated with muscle recovery and memory formation. 

Usage

CJC-1295 assists in muscle growth, fat loss and sleep improvement. This peptide can also increase energy in adults, quicken metabolism and aid in anti-aging benefits.

CJC-1295 and Ipamorelin are often taken together in order to maximize the amount of growth being released into your body. Ipamorelin, while having a similar effect as CJC- 1295, only works in the body for a short term (only a few hours), while CJC-1295 takes a little while to work, but will stay in the body for over a week. The combination CJC-1295/Ipamorelin provides a steady release of natural human growth hormone production in the pituitary over time and delivers more effective results for most people compared to CJC-1295 alone. 

Mechanism of Action

CJC-1295 prompts the secretion of human growth hormone (HGH) in the body through the pituitary gland. 

HGH is necessary for many systems in the body and regulates much more than just growth.  After around age 30, the amount of HGH in the body starts to decrease and sometimes very rapidly. This decrease of HGH is an innate process and mostly responsible for lower energy and muscle mass, increased inability to build new muscle, increased trouble losing or maintaining weight, weakened immune system, decreased healing efficiency and increased signs of aging.

Administration

Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.

Before administering CJC-1295/Ipamorelin always be sure to use a clean and sterile syringe.

  1. Hold the vial upright and insert the syringe in the center of the cap.
  2. Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
  3. Before administering the syringe, use alcohol to cleanse the area of skin.
  4. Pinch the skin around the area to be injected, leave about 2 cm on each side.
  5. Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
  6. Depress the plunger fully, until the syringe is empty, and carefully draw out.

Two types of CJC 1295:

GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).

The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it’s half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.

The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.

Safety:

It is recommended when using a long-acting CJC molecule to have ‘hormone holidays’ of three months each three to six months, to allow the pituitary to ‘recover’. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.

The ‘hormone holidays’ may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.

Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.

Dosage

Dosage Amount:300mcg of CJC-1295/Ipamorelin daily

Dosage Frequency: 300mcg once daily or 150mcg twice daily

CJC-1295/Impamorelin should be taken daily for 12-16 weeks at a time

CJC-1295 take approximately 1-4 hours to reach peak serum levels, while Ipamorelin works quickly and is typically cleared out of the system rapidly as its half life is only about two hours.

Doses should be taken on an empty stomach, over one hour before and after eating.

What is Ipamorelin?

As stated previously, Ipamorelin has an entirely different mechanism of action from CJC 1295 and mimics the hormone ghrelin. Ghrelin is one of three hormones the pituitary gland releases to regulate the release of growth hormone. Ghrelin is responsible for fat breakdown in the body to use as energy and also prevents muscle breakdown.

Ipamorelin

Ipamorelin is within a class of what are called growth hormone secretagogues, which aid the body’s production of endogenous growth hormone. Users report accelerated fat loss, improved sleep, mood, increased energy, as well as long term growth hormone production. That is especially evident when programmatically combined with CJC 1295. After a cycle, the body sees a prolonged boost in hGH production far beyond their initial dose, thus allowing longer-term maintenance of benefits. 

Ipamorelin does this by stimulating the pituitary gland to release growth hormone naturally by its action as an analog to the well-known hunger hormone ghrelin.  Unlike a lot of other GHRP’s, however, Ipamorelin does not have a laundry list of negative side effects like elevated cortisol or increased appetite, which allows patients to use it for a broad range of issues and goals. Many patients use Ipamorelin for a short amount of time (~3 months) for fat loss benefits, increased metabolism, and general improvements in their body composition. 

Growth hormone production decreases by about 15% with each decade of life, resulting in decreased mental and physical function. Thus, why hGH secretagogues may be beneficial for those seeking to maximize performance in sports, the gym or for aesthetics.

Why Combine CJC 1295 and Ipamorelin?

CJC 1295 by itself is a powerful anti-aging protein that increases HGH levels.  HGH levels naturally decrease as we age. Increasing them leads to fat loss and increased muscle growth.  When CJC 1295 is combined with Ipamorelin, there is a synergistic effect on growth hormone levels. The benefits are said to increase as much as five times with the combination treatment overusing CJC 1295 alone.

CJC 1295 takes from 1-4 hours to reach peak levels in the bloodstream, but Ipamorelin works much faster. CJC 1295 has a very long half-life, whereas Ipamorelin has a half-life of about 2 hours, so it’s cleared from the body quite quickly. Combining these two proteins ensures a rapid onset from Ipamorelin with lasting effects from CJC 1295. The one advantage these compounds have over other hormone stimulating treatments is that they don’t act on other hormones, meaning they have less undesirable side effects.

Benefits of CJC-1295 / Ipamorelin

There are several documented benefits from taking CJC 1295 and Ipamorelin:

  • Increase in bone density – injuries due to a loss of bone density can increase as we age.
  • Increased cardiovascular strength and muscle mass increase – higher muscle mass decreases body fat by increasing your body’s metabolic rate.
  • Fat burning – an increase in your basal metabolic rate will burn more calories throughout the day.
  • Increase in sex drive – this goes for both men and women.  It goes without saying that a lack of proper sexual function has an impact on our mental health.
  • Improved injury recovery – using a hormone replacement program decreases the recovery time for soreness and acute musculoskeletal injuries.
  • Strengthened immune function – CJC 1295 helps you get sick less often.
  • Improvement in cognition and memory – mental clarity and focus are improved.
  • Increased insulin sensitivity – an increase in insulin sensitivity means your overall triglyceride levels are decreased.  Lower blood sugar levels burn more body fat.
  • Improved sleep quality – better sleep means better overall mental and physical health.

Why Should You Combine Ipamorelin and CJC-1295?

Ipamorelin and CJC-1295 are known to work best when used in combination. CJC-1295 can take around 1-4 hours to achieve maximum serum concentration. On the contrary, Ipamorelin has a much shorter half-life of about 2 hours. When used in combined therapy, both peptides are able to provide a lasting impact with CJC-1925 and rapid onset due to Ipamorelin. Both of these compounds are highly specific at increasing the concentration of growth hormone in comparison to others. Most of the other peptides can enhance cortisol concentration. However, neither CJC-1295 nor Ipamorelin have such an impact on other hormones in the body. This is a great advantage as the natural body metabolism is not altered.

Who Is A Good Candidate For Ipamorelin /CJC-1295?

Ipamorelin /CJC-1295 can help people over 30 years of age to have a faster metabolism, more energy, and stay in better shape. Ipamorelin /CJC-1295 is not a hormone itself. Hence, it is considered a low-risk and safe option based on current research. However, Ipamorelin /CJC-1295 is made available only for research purposes, although this may change in the future.

What Can I Expect From CJC 1295 / Ipamorelin Treatment?

Let’s look at an example of what you can expect in your first few weeks of treatment with CJC 1295 / Ipamorelin.

Week 1:  You will see an increase in your quality of sleep. Quality, not quantity. It doesn’t make you tired; it just helps you sleep better. Your dreams will become more vivid. You will find yourself waking up more refreshed and not tossing and turning during the night.

Week 2:  You will begin to see a shorter recovery time during your workouts. Some people report being able to work out on more days of the week because their bodies feel less sore.

Week 3-4:  Mental clarity and focus will be noticeably improved. So will your skin elasticity, so you’ll look younger. Collagen production amps up when growth hormone levels increase, and this produces changes in your skin.

Week 6:  Your overall body composition will begin to change. You will gain muscle mass, lose fat and burn more calories at rest.

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