Diabetes Drugs For Weight Loss

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Diabetes Drugs For Weight Loss

Diabetes Drugs For Weight Loss is More Personal, Way More Affordable and Better Than All Other Diets.

Diabetes is a serious condition that, according to the National Institute of Health, may affect 1.5 million Americans. A proper diet is crucial for all diabetes patients. Are you looking for the right diet supplements that can help you control your blood sugar? The following guide has been specially prepared to help you make the right choice while choosing diabetic medications.

Diabetes is common in people who are overweight or obese. The risk for having type 2 diabetes increases if you are overweight and does not decrease if you lose weight. Being overweight influences how your body uses insulin, one of the hormones that removes sugar from your blood. Diabetes also has other effects on your body, such as damage to blood vessels and nerves.

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Why does diabetes medication cause weight changes for some people?

Diabetes medications cause weight changes by affecting how sugar is used by the body. Insulin is a hormone that helps your body to turn sugar from food into energy for your cells. Insulin helps sugar move from your blood into your cells. This movement lowers your blood sugar.

But when there’s too much sugar in the blood, insulin tells your liver to turn that sugar into fat. This added fat can lead to weight gain over time.

When people use insulin as a medication, it acts like natural insulin. Until your blood sugar is better controlled, this sugar-into-fat process can keep happening. This is why insulin’s weight gain side effect is most expected when you first start it. This side effect also applies to medications that tell your body to make more insulin.

On the flip side, some diabetes medications can cause weight loss by getting rid of extra sugar in your body. Less sugar in the blood means there’s less sugar available to change into fat. So if a medication works by removing sugar from the blood, weight loss is a possible side effect.

Is weight gain or weight loss a more common side effect of diabetes medication?

Neither weight gain nor weight loss are more common with diabetes medications. There are several different types of diabetes medications available. They work in different ways to help lower blood sugar. The risk of weight gain or weight loss depends on the medication. 

Weight gain can discourage people from continuing their medications. And when people stop taking their diabetes medications, their risks of diabetes complications go up. Make sure to let your healthcare provider know if you notice any big changes to your weight. They may recommend changes to your medications to better manage this side effect.

How long do you have to take diabetes medications before weight changes take effect?

People taking diabetes medications often see weight changes within the first few months. For instance, much of the weight gain experienced by people taking insulin may happen during the first 6 months. This can vary from person to person, depending on different things like diet and exercise. We’ll discuss more details about weight changes for common diabetes medication next.

Which diabetes medications can cause weight gain?

There are four main groups of diabetes medications that can cause weight gain. A feature they all share is that they work by affecting insulin in the body. As mentioned above, medications that affect insulin levels in your body can cause weight gain.

Insulin

Insulin is one of the most commonly used diabetes medications. Most forms of insulin cause weight gain. People taking insulin for Type 2 diabetes gain an average of 4 pounds during the first year they’re using it. But some people can gain 11 pounds or more during this timeframe.

Sulfonylureas

Sulfonylureas are another common group of diabetes medications that can cause weight gain. They work by stimulating the pancreas to release insulin. Remember, more insulin in the body means more insulin is available to turn blood sugar into fat. On average, people taking sulfonylureas gain about 5 pounds.

Examples of sulfonylureas include:

  • Glimepiride (Amaryl)
  • Glipizide (Glucotrol)
  • Glyburide

Thiazolidinediones (TZDs or “glitazones”)

Another common group of medication that causes diabetes weight gain is thiazolidinediones (TZDs). These medications are also known as “glitazones.” They lower blood sugar by making the body more sensitive to insulin. They also affect genes that are involved in fat formation. People taking TZDs can gain about 6 to 9 pounds during the first 6 months and up to 11 pounds over 3 to 5 years.

The two FDA-approved TZDs are:

  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)

Meglitinides (“glinides”)

Meglitinides (also called “glinides”) are another group of diabetes medications. Similar to sulfonylureas, they cause the pancreas to release more insulin. People can gain up to 7 pounds during the first 3 months of starting glinides.

The two available glinides are:

  • Nateglinide (Starlix)
  • Repaglinide

Which diabetes medications can cause weight loss?

There are four types of diabetes medications that can cause weight loss. These medications each work differently from those already discussed.

GLP-1 agonists

Glucagon-like peptide-1 (GLP-1) agonists are a group of medications growing in popularity when it comes to diabetes and weight loss. GLP-1 is a hormone in our bodies that tells our pancreas to release insulin after we eat. It also helps us feel full in between meals. GLP-1 agonists act like GLP-1 does in the body.

Some studies have shown that people with diabetes lost as much as 13 pounds when using a GLP-1 agonist. Other studies have suggested GLP-1 agonists cause more modest weight loss (about 2 pounds). The amount of weight loss can vary, depending on which medication and what dose is used. Many studies that looked at diabetes weight loss from GLP-1 agonists ran for between 6 and 12 months.

There are several GLP-1 agonists FDA-approved for diabetes, including:

  • Dulaglutide (Trulicity)
  • Exenatide (Byetta, Bydureon BCise)
  • Liraglutide (Victoza)
  • Semaglutide (Ozempic, Rybelsus)

SGLT2 inhibitors

Another group of diabetes medications called sodium-glucose cotransporter 2 (SGLT2) inhibitors can cause weight loss. SGLT2 inhibitors remove sugar from the blood through urine. Less sugar in the blood means less sugar is available to be turned into fat.

People taking SGLT2 inhibitors may lose about 4 to 6 pounds while taking them. It’s possible to start noticing weight loss after taking these medications for 6 weeks.

SGLT-2 inhibitors include the following medications:

  • Canagliflozin (Invokana)
  • Dapagliflozin (Farxiga)
  • Empagliflozin (Jardiance)

Metformin

Metformin is one of the most prescribed diabetes medications. It mainly lowers the amount of blood sugar made by the liver and makes the body more sensitive to its natural insulin. It doesn’t always cause weight loss for all who take it. But studies have shown some people may lose up to 6 pounds after taking metformin for a year.

Pramlintide (Symlin)

Pramlintide (Symlin) is a lab-made form of the hormone amylin. Amylin slows down food movement through the stomach and prevents your liver from making sugar. Pramlintide acts like amylin does in the body. This medication can cause most people to lose about 4 pounds. For people with obesity, they may lose up to 7 pounds with pramlintide.

Which diabetes medications are likely to have little or no effect on your weight?

Not all diabetes medications affect body weight. Some medications have little to no effect on weight for most people. Healthcare providers sometimes call these “weight-neutral” diabetes medications.

Dipeptidyl peptidase-4 (DPP-4) inhibitors

Dipeptidyl peptidase-4 (DPP-4) inhibitors (or “gliptins”) are a commonly-used group of diabetes medications. They lower blood sugar by helping to raise natural levels of GLP-1 in the body. Studies have shown they have little effect on weight.

Examples of DPP-4 inhibitors include:

  • Alogliptin (Nesina)
  • Linagliptin (Tradjenta)
  • Saxagliptin (Onglyza)
  • Sitagliptin (Januvia)

Can weight gain or loss from diabetes medication be prevented?

Weight changes from diabetes medications may be preventable. Diet and exercise play an important role in managing diabetes. These healthy lifestyle changes can help lower blood sugar and lower weight. It’s best to discuss with your healthcare provider what changes would be best for you.

Weight loss considerations

We know that weight loss, especially when it is rapid, may affect other functions in your body. This means it is important to make sure you are still meeting your body’s requirements for essential nutrients.

Keep hydrated – drink plenty of water every day. GLP-1 analogues can reduce your thirst due to nausea. Dehydration can increase nauseous feelings and also affect kidney function. (1) Eating smaller low-fat meals more frequently often helps with nausea.

Exercise – Weight loss causes fat tissue loss but also reduces muscle mass and can also decrease the strength of bones by reduced bone mineral density. Both decrease in muscle mass and bone strength may lead to an increased risk of falls and fractures. Studies reveal that diet-induced weight loss alone can lead to bone loss that is much greater than if weight loss is accompanied by exercise. (2)

How can you support your body during weight loss?

  • Visit an exercise physiologist to create a safe and effective exercise plan for your lifestyle that keeps your muscles strong. Strong muscles support your bones and joints, helping to prevent falls. You can visit an exercise physiologist with a referral from your doctor under a care plan or see one privately.
  • Visit a dietitian to ensure that your body has the nutrients it needs to lose weight safely and maintain as much muscle as possible. An accredited practising dietitian can give you individualised advice on healthy eating. Again, obtain a referral through your doctor if you want a care plan, otherwise you can see a dietitian and pay privately.
  • Ask your doctor to check the vitamin and mineral levels in your body, for example: vitamin B12 and your bone density. Check with your doctor before taking supplements.
  • Keep regular appointments with your doctor and allied health team to reassess your overall health while losing weight.
  • Keep hydrated – drink plenty of water.

The bottom line

Diabetes medications are important for lowering blood sugar levels for people with diabetes. But some medications can cause weight gain or weight loss. Insulin tends to cause the most weight gain. On the flip side, GLP-1 agonist medications tend to cause the most weight loss. Some medications, such as DPP-4 inhibitors, have little to no effect on weight.

Eating a healthy diet and exercising are important in maintaining a healthy weight. Work closely with your healthcare team to determine the best diabetes treatment regimen for you.

 

 

 

 

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