GNC products for weight loss take the guesswork out of losing weight. GNC diet nutritional pills, vitamins, protein shakes, and other supplements are designed to help you lose weight faster than ever before. Dual action ingredients in GNC diet pills work to provide quick results and extended health benefits for a lifetime. It’s never been easier to find a wide-range of effective fat burners, appetite suppressants, and other essentials from GNC’s selection of diet pills.
GNC Weight Loss Pills: Picking What Works
In compiling this list of products, I made it a point to do my homework on the ingredients to background check these fat burners. I also looked at what other users had to say of their own results.
Biorhythm Adrenalean
This is a heavy hitter when it comes to fat loss. As with other fat loss supplements, you may feel a bit jittery, so keep an eye on your stress levels, especially if you are susceptible to anxiety. There are people who have reported anxiety and extra tingling as well. The main reason for this is because of the extra amount of caffeine that is present in this product. However, along with the caffeine, it also contains Hoodia Gordonii. This is believed to have appetite suppressing properties and aims to help you to stick to your diet and control cravings.
If you combine Yohimbine along with it, this may assist you in getting rid of fat even more quickly. This product helps in getting rid of the fat that is mostly stored in the lower regions of abdomen.
Z-Burn
Of the many GNC weight loss pills that you will find, this one is a little different. Most of the GNC weight loss pills make it harder for you to sleep but allow you to put out more energy in more exercise and increase your metabolic rate. This product however, will help you sleep a lot more. The main aim is to increase the rate at which your body oxidizes fat. Even when you are sleeping, your metabolic rate may be improved a great deal. This is different than most GNC weight loss pills, which are usually a stimulant formula. This is also for people who are more focused on displacing fat with muscle mass than simply losing pounds.
As you will be getting more sleep, you will wake up feeling more energized and so you can use that extra energy to put in more hours of work exercising and building the chiseled physique that you’ll be revealing when you shed those extra pounds.
Further, Z burn improves the amount of cortisol control that your body has. Cortisol is a stress hormone that also causes us to store unnecessary fat. The product has been designed to combat the problem of muscle loss which generally follows dieting. This is a significant disadvantage to focusing on fat loss and you should try and avoid it for the sake of your overall progress and growth. Choosing the best GNC diet pills can help you in keeping muscle loss in check during dieting.
The components contained in Z-Burn include:
- Z-Burn uses ZMA (zinc magnesium aspartame) which has been researched thoroughly and is known to offer numerous fat burning benefits.
- It also has chromium which is handy in regulating the level of blood glucose and even insulin levels too.
- The L – Glutamine is an important amino acid which also is indicated to improve your immune system.
- Melatonin helps in improving sleep and will allow you to rest more deeply.
- L- Theanine will aid in relaxation which is also helpful before bedtime.
This product is ideally meant for those who tend to get tired and lethargic when they are dieting. This product will give you ample rest and help you feel energetic.
GNC Total Lean CLA
CLA stands for conjugated linoleic acid and is known to have special weight loss properties. This is what makes it one of the best GNC diet pills that you can use.
CLA improves the speed at which stored body fat is converted to fuel. Further, your rate of metabolism is also going to improve significantly. The product is made from natural ingredients and so the risk of any side effects is extremely low.
GNC Total Lean CLA uses raspberry ketones and contains green coffee beans. It is this blend of the two that makes it an effective product for efficiently converting fat to fuel and thereby speeding up your metabolism significantly.
It is important to note that owing to the presence of coffee beans it may sometimes cause a little tingling and slight anxiety.
Best Supplements For Weight Loss At GNC
Cellucor Super HD
The Cellucor brand is well-known for churning out quality supplements, and their Super HD formula definitely tops this list. It’s not only the highest rated thermogenic fat burner on the GNC website, but we have also personally tested it with great results.
Like most of the weight loss pills you’ll see on this page, it contains a number of different stimulants to not only help curb your appetite, but also help with boosting your energy levels.
One additional component to Super HD is it’s nootropic effect. Some of the ingredients in their formula have been associated with feelings of calm and focus, something that is certainly a plus when your in the gym.
2: Meratrim
Meratrim is a stimulant free plant based weight loss supplement.It’s all natural, gluten, soy, and sugar free, and it makes the very reasonableclaim that you can start losing weight in 2 weeks.
They call it a Fruit and Flower formula, with both of its two key ingredients housed within an 800 mg proprietary blend.
Garcinia Mangostana is the Fruit.It is said to work by suppressing appetite, blocking fat absorption, and by increasing the use of stored fat.
Sphaeranthus Indicus is the Flower.It may help control the way your body uses glucose.
According to preliminary researchhowever, it seems that a 150 pound person would need to take over 2 grams per day to achieve the benefits.
There is actually a studyshowing that over a 16 week time period, subjects taking Meratrim lost over 8 pounds more than those using the placebo.
One thing to note here is that because Meratrim is a popular product on Amazon, there are hundreds of customer reviews, and it’s not good news. There are more 1 star reviews than 4 and 5 star reviews combined.
There are no complaints about side effects to speak of.
3: Lipozene
Lipozene claims you can lose weight without changing your lifestyle – you can still eat all your favorite foods and you don’t need to increase your exercise routine.Personally, I’m very suspicious of products that make claims like these, but it’s a popular supplement so it’s worth looking into.
The active ingredient in Lipozene is 1500 mg of Amorphophallus Konjac from the Konjac Root, aka Glucomannan.It’s a water soluble fiber that expands in your stomach.
The idea is that becomes a gel-like substance in your stomach that makes you feel full.
Obviously, if you feel full, you’ll eat less, so even though you may be eating the same foods you always ate, the fact that you’ll feel more full means you’ll naturally eat less.
This claim is based on a small study of 20 obese participants who were instructed not to change their eating or workout routines.
The study was conducted over 8 weeks time.
The group taking the Glucomannan lost 5.5 pounds while the placebo group lost only 1.5 pounds.
Of course, if you really want to lose weight and keep it off, you will need to change your diet and activity level, but there’s something to be said for using Lipozene as a non-stimulant aid to help the process along.
GNC sells a 2 bottle package, each bottle a 60-count, for $17.88. At the recommended dosage of 2 pills taken 3 times a day before meals, the package will last just short of 3 weeks.
4 – Zantrex 3 Fat Burner
We’ve been getting a lot of feedback from visitors on Zantrex 3. There’s actually two different formulations for this supplement…a Red bottle and a Blue bottle.
Personally speaking, and this is reflected in the various reviews we’ve been getting, I think the Zantrex 3 Blue bottle is superior. It contains 3 fat burning stimulants such as yerba mate, guarana, and damiana extract, as well as caffeine, so it packs a bit of a punch.
But it does work GREAT for providing energy and motivation for the gym, as well as helping to curb appetite.
I experienced no side effects at all from the Blue Bottle, however the Red Bottle gave me various side effects like headaches, dizziness, and a rapid heart beat.
5 – BIORhythm AdrenaLean

If you want to see a major change in how you feel and function on a daily basis while using your weight loss support product, BIORhythm AdrenaLean is one to consider.
It is a more powerful product, so there will be a risk of side effects such as possibly feeling jittery, anxious, and having issues sleeping.This is due to the fact the product does contain stimulants including caffeine, so will rev up your central nervous system.
But in turn, this is also what allows it to give you the significant energy boost, which will be appreciated as you head into your next workout session.
In fact, Adrena Lean doubles as both an effective weight loss pill AND a pre workout supplement.
Even though the product claims to have no jittery side effects, it does contain caffeine so you need to know your own body.
Many people are sensitive so if you do react, you will notice it.

It also contains Hoodia Gordonni, which some market for weight loss, and its appetite suppression ability.
On the contrary, according to the Mayo Clinic, it has not been scientifically proven, and the Federal Trade Commission calls such claims misleading.
Yikes!
You’ll also take in Yohimbine, which can help to assist with the burning of stubborn body fat stores, especially in the lower legs or abdomen.
Finally, you’ll take in synephrine, which also helps to stimulate the CNS, providing you a boost when you need it.
This product should be taken in a 1-2 capsule does per day, starting with one to assess your tolerance. You’ll pay $29.88 for a 60 capsule bottle, putting in on par with most other fat burners in price.
Best Fat Burners at GNC
After extensive research, here is my selection of the best fat burners at GNC.
1. Jym SS8

When updating this article in 2021 we noticed that GNC had added the Jym SS8 fat burner to their selection.
This changes everything for the rankings of this article.
Jym SS8 contains many great ingredients in good dosages.
The formula has a hefty caffeine dose of 300mg per day.
Along with 500 mg dose of acetyl-l-carnitine which helps the body use fat cells as fuel.
The formula also has cayenne pepper fruit extract which helps increase the metabolism and calories burned throughout the day.
We also see that it has the green tea leaf extract which is included in most top fat burners.
(HEADS UP! Even though it’s #1 at GNC, doesn’t mean it’s the best one on the market.
Jym SS8 Key features:
- Contains proven fat burners in good dosages
- Has the acetyl-l-carnitine and cayenne pepper extract
- No proprietary blends
- Thermogenic effect
- High caffeine dose – 300mg (may cause side effects)
If you are limited to buying something at GNC, Jym SS8 is probably the best option in 2021
2. Universal Nutrition Animal CUTS

This supplement may be one of the best fat burners at GNC for guys seeking that totally shredded appearance.
With a massive formulation of 38 ingredients (all of which are hidden in eight different proprietary blends), it aims to hit every aspect of weight loss to really accelerate cutting cycles.
Part of its working processes includes:
- Reducing the fat-inducing stress hormone cortisol with ashwagandha.
- Lowering water retention through the utilization of dandelion root.
- Boosting the metabolism with the inclusion of the stimulant caffeine.
- Improving mood with huperzine to alleviate “comfort eating”.
3. MuscleTech Hydroxycut
These weight loss pills (as opposed to a fat burner powder) concentrate on the process of thermogenesis to elevate fat loss by boosting the metabolism.
Its key ingredients are:
- Caffeine—an essential thermogenic fat burner ingredient, although the 270 mg dose may be too intense for some.
- Green coffee—boosts the metabolism and can slow down the rate fat is absorbed from food.
- Coleus forskohlii—acts both as a thermogenic and creates enzymes which break down fatty acids—although, at a dose of 100mg, it’s less than half what’s required for fat loss.
- Yohimbe—boosts energy levels and helps with fat burning.
It’s a solid fat-killer with scientifically proven ingredients. But, with just six active compounds, it’s not as potent as the best weight loss products available elsewhere.
4. C4 Ripped

Possibly one of the best fat burners at GNC for guys looking to both drop weight and gain the power of a pre-workout supplement.
For weight loss, this GNC thermogenic product includes:
- Caffeine to boost the metabolic rate.
- Cayenne pepper which both burns calories and helps with fat oxidation.
- Coleus forskohlii to boost fatty acid breakdown.
Additionally, to enhance workout performance, it contains:
- Tyrosine—increases energy levels, boosts focus, and relieves stress.
- Velvet bean—can enhance protein efficacy and improve recovery times.
Sadly, despite containing some proven ingredients, they’re all hidden in proprietary blends—hence their effectiveness is debatable. The GNC weight loss pills reviews for this supplement report underwhelming results.
5. Cellucor SuperHD

Like the Ripped product above, this is another weight loss supplement from Cellucor. While it remains one of the best fat burners at GNC—yet again, every one of its 11 active ingredients is unquantified.
With a total proprietary blend dose of 521 mg—it’s unlikely that these ingredients will pack enough power to really accelerate weight loss.
This supplement sticks with the usual fat-burning ingredients of yohimbe, caffeine, and green tea—but also includes the novel compound of blue whiting protein hydrolysates.
This fish extract has been shown in some studies to reduce the appetite—although further research is required.
6. Grenade Thermo Detonator

At #5 in this best fat burners at GNC list is a product which claims to declare war on fat. The company behind it says it will increase energy, prevent stimulant crashes, and help to shed unwanted weight.
The truth is, many of its 14 ingredients are proven and effective pound-shedders, including:
- Citrus aurantium—a legal alternative to the banned GNC diet pills with ephedrine—it boosts energy levels and burns fat through thermogenesis.
- Raspberry ketones—can increase the rate of lipolysis (fat breakdown).
- Green tea extract—elevates fat oxidation, has a thermogenic effect, and stimulates enzymes which breakdown fatty tissue.
Despite its effective ingredients, combining them all together in its “Thermo Detonator Proprietary Blend” means that all doses are hidden. Probably because they’re too weak to be productive.